Original Article

Clinical Features of Cases of Vogt-Koyanagi-Harada Syndrome


  • Osman Melih Ceylan
  • Yusuf Uysal
  • Adem Türk
  • Gökçen Gökçe
  • Fazıl Cüneyt Erdurman
  • Güngör Sobacı

Received Date: 05.04.2010 Accepted Date: 17.06.2010 Turk J Ophthalmol 2010;40(5):250-254


To report the clinical features of our cases of Vogt-Koyanagi-Harada (VKH) disease.

Material and Method:

Medical records of totally 10 VKH patients who presented to our clinic between January 2001 and January 2010 were analyzed retrospectively.


The mean age of 10 male patients was 21.9 years. The mean follow-up period was 16.2 months. Seven cases had bilateral involvement and three had unilateral. The mean initial visual acuity was 0.51 in a total of 17 eyes. Fourteen eyes had anterior uveitis and twelve eyes had vitritis. Optic disc hyperemia was present in sixteen eyes. Twelve eyes had exudative retinal detachment and five eyes had areas of slight retinal depigmentation. All cases were evaluated with fundus fluorescein angiography and ultrasonography. Auditory disturbances were seen in two cases. On first examination, pleocytosis was detected in the cerebrospinal fluid samples from six patients. Integumentary findings were seen in four cases. All subjects were treated with high-dose oral corticosteriod, but three of them additionally received cyclosporine therapy. The mean final visual acuity was 0.86.


In VKH disease, visual prognosis is generally good, especially in cases presenting in the early period. Treatment with corticosteroids is quite effective in improving the visual acuity, and immunosuppressive drugs may be needed in cases of corticosteroid resistance.

Keywords: Treatment outcome,Uveitis,Vogt-Koyanagi-Harada disease

Full Text (Turkish)