Original Article

Comparison of Diagnostic Accuracy of MRA and GPS Algorithms Using HR III Device in Glaucoma Patients


  • Mahmut Oğuz Ulusoy
  • Esin Fatma Başer
  • Recep Göktuğ Seymenoğlu
  • Rasim Özcan Kayıkçıoğlu

Received Date: 05.02.2013 Accepted Date: 07.11.2013 Turk J Ophthalmol 2014;44(2):108-114


The aim of this study is to evaluate the diagnostic accuracy of Moorfields regression analysis (MRA) and glaucoma probability score (GPS) and to measure the agreement between these two programs in classifying eyes as normal or abnormal.

Materials and Methods:

The study included 150 glaucoma patients followed in our glaucoma unit and 120 control subjects without glaucoma. All subjects underwent total ophthalmological examination, standard achromatic perimetry, and imaging of the optic nerve head with the Heidelberg Retina Tomograph II (HRT), using HRT III software, Version 3.0. The HRT parameters were compared between the two groups. The diagnostic accuracies of the two classifications were measured when the borderline was taken as either normal (highest specificity criteria) or abnormal (highest sensitivity criteria). The agreement between them was calculated using the kappa (κ) coefficient.


All HRT parameters except height variation contour in our study showed statistically differences between the control and glaucoma groups (p=0.000). The parameters with the highest area under curves were GPS global score (0.817), vertical cup/disc ratio (0.816), cup/disc area (0.808), and cup area (0.783). According to the highest specificity criteria, MRA had a sensitivity of 66% and specificity of 89.1% and GPS had a sensitivity of 62.7% and specificity of 81.6%. According to the highest sensitivity criteria, MRA had a sensitivity of 85.3% and specificity of 68.3% and GPS had a sensitivity of 90% and specificity of 60.8%. A moderate agreement of 65.9% (178 eyes) with a κ coefficient of 0.47 was found between MRA and GPS.


In conclusion, GPS and MRA had a similar sensitivity, but the specificity of MRA was found to be higher than that of GPS. A moderate agreement was found between these analysis programs.

Keywords: Glaucoma, heidelberg retina tomograph 3, glaucoma probability score, moorfields regression analysis

Full Text (Turkish)