Original Article

Comparison of the Effects of Latanoprost/Timolol Maleate and Dorzolamide/Timolol Maleate Fixed Combinations on Intraocular Pressure and Diurnal Variation in Patients with Primary Open-angle Glaucoma

  • Şahin M. Sevim
  • Didem Esen
  • Banu Torun Acar
  • Bülent İ. Buttanrı

Received Date: 07.12.2009 Accepted Date: 19.01.2010 Turk J Ophthalmol 2010;40(2):76-79


To compare the intraocular pressure (IOP)-lowering effect and diurnal variation of Latanoprost/Timolol Maleate (LTFC) and Dorzolamide/Timolol Maleate(DTFC) fixed combinations in patients with primary open-angle glaucoma (POAG).

Material and Method:

96 eyes of 48 patients followed with the diagnosis of PAOG were included in this prospective study. The patients were randomly divided into two groups: the first group (48 eyes) was treated with LTFC and the second group (48 eyes) was treated with DTFC. At the 3rd month of therapy, the IOP was measured every 2 hours between 8:00 am and 8:00 pm.


Both treatments significantly reduced the IOP during the daytime at the 3rd month. The diurnal variation was significantly lower in the LTFC group (p<0.01).


Three-month therapy with LTFC and DTFC effectively reduces IOP in POAG patients during the daytime. LTFC provides better reduction in the diurnal variation.

Keywords: Latanoprost/Timolol Maleate fixed combination, Dorzolamide/Timolol Maleate fixed combination, diurnal variation of intraocular pressure

Full Text (Turkish)