Original Article

Photodynamic Therapy Versus Combined Photodynamic Therapy - Intravitreal Triamcinolone Acetonide in Treatment of Subretinal Neovascular Membrane Associated with Age-related Macular Degeneration

  • Mehmet Çakır
  • Osman Çekiç
  • Neşe Molla
  • Şükrü Bayraktar
  • Ömer Faruk Yılmaz

Received Date: 15.01.2008 Accepted Date: 04.04.2008 Turk J Ophthalmol 2008;38(2):144-151


To evaluate the efficacy of ocular photodynamic therapy (PDT) and combined PDT-intravitreal triamcinolone acetonide (IVTA) in the treatment of subretinal neovascular membrane (SRNM) due to age-related macular degeneration (AMD) in terms of visual acu-ity changes and retreatment rates.

Materials and Methods:

A total of 64 eyes of 51 patients with SRNM due to age related macular degeneration (AMD) were treated with PDT alone (1 st group, n=44) or combined PDT- 4 mg IVTA (2nd group, n=20). Functional outcome was evaluated by comparing visual acuitiy in both groups. LogMAR visual acuity was used for statistical analysis. Retreatment rates were also evaluated.


The mean age was 72 years (range 52 to 85 years), and the mean follow-up period was 8.5 months (range 3 to 27 months). Of 64 eyes, 27 (42%) were classified as classic, 34 (53%) as occult and 3 (5%) as minimally classic. In 1 st group no significant change was noted between initial (1.04 ± 0.09, mean ± SEM) and final (1.05 ± 0.07) logMAR visual acuity (P= 0.80). Likewise, initial visual acuity (0.98 ± 0.08) did not improve in the 2nd group in last exa-mination (1.05 ± 0.15, P=0.60). Average PDT rate was 1.9 ± 0.1 in the 1st group, 1.4 ± 0.1 in the 2nd group (P=0.01).


Visual outcomes of PDT and combined PDT-IVTA in the treatment of SRNM were found similar at a mean follow up of 8.5 months. However, it should be kept in mind that retreatement rate is less in combined group.

Keywords: Photodynamic therapy, intravitreal triamcinolone, subretinal choroidal neovascular membrane, age-related macular degeneration

Full Text (Turkish)