Original Article

Retinopathy of Prematurity; Risk Factors, Prognosis and Treatment


  • Sibel Kocabeyoğlu
  • Sibel Kadayıfcılar
  • Bora Eldem

Received Date: 15.04.2010 Accepted Date: 11.02.2011 Turk J Ophthalmol 2011;41(3):128-132


To evaluate the prevalence, related risk factors, treatment and follow-up results in cases of retinopathy of prematurity (ROP).

Material and Method:

Medical records of 405 premature infants who attended our clinic between August 1999 and September 2004 were retrospectively screened. Among these patients, 379 infants were followed up in our neonatology unit and 26 were referred to us from other clinics. Indirect diode laser photocoagulation and/or cryotherapy were performed when prethreshold or threshold ROP was detected. Surgery was performed in stage IV-V ROP.


ROP was detected in 88 out of 405 infants (21.72%). At the first examination, stage I ROP was detected in 18 eyes (10.4%), stage II - in 67 eyes (38.72%), stage III - in 82 eyes (47.39%), and stage IV-V – in 6 eyes (3.46%). Indirect diode laser photocoagulation was applied to 34 eyes with stage II and in 47 eyes with stage III ROP. Ten eyes with threshold ROP and 4 eyes which progressed to threshold ROP were treated with cryotherapy. Scleral buckling was performed in 3 eyes that progressed to stage IV ROP. At the first examination, 2 eyes with stage IV-V ROP were treated with pars plana vitrectomy (PPV).


In our series, the most important risk factors for development and progression of ROP were found to be low birth weight, low gestational age, mechanical ventilation and multiple pregnancy. Effective screening, follow-up and appropriate treatment are important for prevention of permanent damage and unfavorable outcome in ROP. (Turk J Ophthalmol 2011; 41: 128-32)

Keywords: Retinopathy of prematurity, low birth weight, low gestational age

Full Text (Turkish)