Case Report

Reversible Posterior Leukoencephalopathy Syndrome due to Intrathecal Methotrexate in a Case with Acute Lymphoblastic Leukemia

10.4274/tjo.91249

  • Osman Okan Olcaysü
  • Sertaç Argun Kıvanç
  • Elif Olcaysü
  • Ahmet Altun
  • Zuhal Keskin Yıldırım

Received Date: 25.04.2013 Accepted Date: 26.08.2013 Turk J Ophthalmol 2014;44(3):243-245

Reversible posterior leukoencephalopathy syndrome is characterized by headache, nausea, seizures, altered consciousness, visual disturbance, and convulsion. It usually develops due to hypertension, eclampsia, autoimmune diseases, blood transfusion, hypercalcemia, hypomagnesemia, and immunosuppressive therapy. The radiological feature of this syndrome is reversible bilateral white matter abnormalities predominantly located in the posterior regions of the cerebral hemispheres. With symptomatic therapy, clinical and radiologic recovery can be achieved. In this case report, we aimed to present clinical and radiological findings of transient posterior leukoencephalopathy syndrome due to intrathecal methotrexate usage in a case with acute lymphoblastic leukemia.

Keywords: Reversible posterior leukoencephalopathy syndrome, acute lymphoblastic leukemia, methotrexate

Full Text (Turkish)